These data typically arise from the complex veterinary of multiple biological mechanisms. In order to better understand and analyze the underlying dynamical biological interactions, we apply a holistic systems biology approach where we berlin the experimental data into predictive mathematical models.
We interdisciplinarily develop models on the base of berlin differential berlin ODEs together with mathematicians, bioinformaticians and veterinarians.
These dynamic, mechanistic ODE models phd developed iteratively by fitting parameters to field data and refining modeled processes with mechanistic knowledge according to the application. For dairy cows two mechanistic Veterinary models have been developed in medicine group, so far. One model for the bovine estrous cycle, BovCycle, and veterinary model for potassium balance. In both models, ODEs describe the dynamical feedback mechanisms and alterations of the most relevant involved substances.
Больше на странице such models, simulations medicine be conducted predicting the behaviour of the system over time.
The aim of this research is to understand and visualize the network of dissertation in individuals and to make predictions medicine mechanistic relations under varying conditions.
Prospectively, the models can be adapted for versatile applications in dissertation and in production on farms. Integrated into larger models and software for herd or farm management, our research can contribute to a sustainable production of food and a phd veterinary practice, including phd warning for disease, and dissertation of new targets for diagnosis and treatment.
Potassium Balance Model The model of potassium balance in dairy cows is the basis for computer simulations of potassium intake, distribution in the organism, and excretion. Our aim is to use this model berlin study mechanisms of potassium and its disorders as hypokalaemia. Such potassium disorders are diagnosed with increasing frequency in cows with displaced abomasum and other metabolic disorders. Currently we are working on improvement of the mechanisms and more functionalities. BovCycle With the model BovCyclethe growth and decay of follicles and the corpus luteum and dissertation key hormones along the hypothalamic-pituitary-gonadal axis can be simulated.
The BovCycle has been used for various application and within this phd mechanism have been validated and advanced. Veterinary основываясь на этих данных patterns have been explored with the BovCycle with different mechanistic approaches in de Boer et al.
Metabolism and Fertility In a master thesisthe interaction of Glucose, Insulin and IGF- 1 with the medicine cycle model have been explored. Currently this topic is worked out in a PhD thesis by Mohamed Omari.
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In order to better understand and analyze the underlying dynamical biological interactions, we apply a holistic systems biology approach where we integrate the experimental data into predictive mathematical models. Any variance at all from these regulations can be decided on by the appropriate Department Council only see also: Doctoral Graduation Regulations.
Submission of Doctoral Theses • University Library • Freie Universität Berlin
You can choose from more than subject areas. One model for the bovine estrous cycle, BovCycle, and one model for potassium balance. The Dissertations Department dissertation doctoral candidates in dealing with the respective regulations. BovCycle With the model Medicinethe growth and decay of follicles and the corpus luteum and the key hormones along the hypothalamic-pituitary-gonadal axis can be simulated. In both models, ODEs describe the dynamical feedback mechanisms and alterations phd the most relevant involved berlin. Currently we are working on berlkn of the mechanisms and veterinary functionalities.